Biological Clocks and the Formation of Human Tooth Enamel

Tooth enamel contains relics of its formation process, in the form of microstructures, which indicate the incremental way in which it forms during enamel formation on teeth (). These microstructures, called cross-striations and striae of Retzius, develop as enamel-forming cells called ameloblasts, which cyclically deposit enamel on developing teeth in accordance with two different biological clocks. Cross-striations result from a twenty-four-hour cycle, called a Circadian rhythm, in the enamel deposition process, while striae of Retzius have a longer periodicity. Unlike other tissues, enamel does not remodel after it forms, leaving those microstructures intact after deposition. Cross-striations and striae of Retzius thus provide evidence of the timing and processes of tooth development, and they indicate how organisms in a lineage differently grow and develop across generations. Researchers have examined these microstructures to investigate human evolution [5].